Non-Muscle Causes of Leg Pain You Shouldn’t Ignore

When leg pain strikes, most people assume it’s a result of muscle strain, perhaps from a workout, long walk, or minor injury. But what if the real reason has nothing to do with your muscles at all?

At Mission Surgical Clinic in Riverside, CA, we often see patients experiencing persistent or unexplained leg pain who are surprised to learn the actual cause lies far beneath the surface. From nerve conditions to vascular problems, there are several non-muscular sources of leg discomfort that require attention.

Here are five surprising causes of leg pain you may not have considered:

1. Peripheral Artery Disease (PAD)

Peripheral Artery Disease is a circulatory disorder caused by narrowing or blockage in the arteries that carry blood to the limbs. This reduced blood flow deprives leg muscles and tissues of the oxygen they need, leading to pain—especially during activities like walking or climbing stairs.

Common Signs of PAD:

• Cramping in your calf, thigh, or hip while walking

• Pain that stops with rest but returns with activity

• Cold feet or legs

• Slow-healing wounds on the legs or feet

Because PAD pain often mimics muscle soreness or fatigue, many individuals ignore the symptoms or assume it’s age-related stiffness. Left untreated, PAD can progress to more serious cardiovascular issues.

2. Sciatica

If you’re feeling a sharp or radiating pain that starts in your lower back or buttocks and travels down one leg, it may be due to sciatica—a condition caused by irritation or compression of the sciatic nerve.

This pain typically affects only one side and can vary from a dull ache to a sudden, electric shock-like sensation. You might also feel numbness, tingling, or muscle weakness in the leg or foot.

Sciatica is often mistaken for muscle strain, especially after a physical activity. However, true muscle pain doesn’t follow the nerve path from your spine to your toes.

3. Deep Vein Thrombosis (DVT)

A far more serious but lesser-known cause of leg pain is Deep Vein Thrombosis—a blood clot that forms in a deep vein, usually in the leg. DVT can be life-threatening if the clot breaks loose and travels to the lungs, causing a pulmonary embolism.

Key Symptoms to Watch For:

• Unilateral leg swelling

• Cramping or tenderness in the calf

• Warmth or redness in the skin over the affected area

• Sudden unexplained leg pain

DVT can occur due to prolonged immobility (like sitting during long flights), certain medications, or underlying health issues. It’s essential to get immediate medical attention if you suspect it.

4. Complex Regional Pain Syndrome (CRPS)

CRPS is a chronic pain condition that typically develops after an injury or surgery. Unlike typical pain responses, CRPS causes intense and prolonged pain that seems out of proportion to the original injury. It most commonly affects an arm or leg and can lead to long-term disability if not treated early.

Typical Symptoms Include:

• Burning or throbbing pain

• Heightened sensitivity to touch or temperature

• Skin changes (swelling, discoloration, temperature shifts)

• Decreased mobility or stiffness in the affected limb

Because CRPS is rare and its symptoms resemble other more common conditions, it often goes undiagnosed. If you’re experiencing ongoing leg pain after even a minor injury, this condition should be considered.

5. Bone Cancer

Though rare, bone cancer can cause persistent and unexplained leg pain—particularly in the longer bones like the femur or tibia. Pain is usually worse at night and does not improve with rest or over-the-counter pain medications.

Warning Signs of Bone Cancer:

• Constant, dull pain that worsens over time

• Swelling or lumps near the pain site

• Difficulty moving the affected limb

• Fatigue and weight loss

Because it mimics more benign conditions like arthritis or pulled muscles, bone cancer is frequently misdiagnosed early on. Imaging and biopsy are typically required for a definitive diagnosis.

When Should You See a Specialist?

Not all leg pain requires a trip to the doctor, but if you’re experiencing pain that:

• Persists beyond a few days

• Worsens over time

• Occurs without physical activity or injury

• Comes with swelling, numbness, or skin color changes

…then it’s time to schedule a consultation.

At Mission Surgical Clinic in Riverside, our team of board-certified vascular and general surgeons can help determine the root cause of your leg pain and provide customized treatment solutions—whether it’s related to circulation, nerves, or something more serious.

How We Can Help at Mission Surgical Clinic

Located in the heart of Riverside, CA, Mission Surgical Clinic offers advanced diagnostic tools and personalized care for patients dealing with unexplained leg pain. Our integrated team collaborates across specialties—from vascular surgery and general surgery to wound care and diagnostic imaging—to ensure no detail is overlooked.

If you’re unsure whether your leg pain is a harmless muscle strain or something more concerning, let our team help you find answers. Early diagnosis is critical in preventing complications and improving your quality of life.

Final Thoughts

Leg pain isn’t always about sore muscles. Conditions like PAD, sciatica, DVT, CRPS, and even bone cancer can all masquerade as simple leg discomfort—yet they carry significantly different implications.

Knowing the difference can save you time, money, and in some cases, your life.

Don’t ignore persistent pain or unusual symptoms. Schedule an appointment with Mission Surgical Clinic in Riverside today and let us help you uncover the real cause behind your discomfort.